This webinar discusses two novel strategies for employing a combination of drones and delivery vehicles, such as trucks, for last mile delivery to homes and businesses. The work is general, but we aim for a healthcare application. The first strategy uses a drone to resupply a truck during the day for same day delivery, as orders are made available at a central depot. The truck delivers the orders to the customers but does not have to return to the depot during the day since it is being supplied by the drone for new orders. The second strategy integrates a truck with a drone. In this case, either the truck or the drone can make both deliveries and pick-ups, and the drone is launched from and returned to the truck. A mathematical model is formulated and solved for each strategy. We show that both strategies offer benefits in customer service and cost of delivery compared to traditional truck delivery only. We focus our work on healthcare and specifically the delivery and pick up of medical supplies and tests (such as COVID tests) in challenged, rural environments. A limited field trial will take place later in 2020.